We’ve found that the ideal time to take Restore 3 is the first thing in the morning or just before going to bed and on an empty stomach. You’ll want to take Restore 3 at least an hour away from food and with at least a 6 oz. glass of water. If taken with food, the enzymes in Restore 3 will simply work on digesting your food, rather than working systemically to break down biofilm and fibrin and other contributors to chronic symptoms.